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A single point mutation leads to an instability of the hetero-octameric structure of yeast phosphofructokinase.

Yeast phosphofructokinase is an oligomeric enzyme whose detectable activity in vitro depends on its hetero-octameric structure. Here we provide data demonstrating that an alanine residue at positions 874 (for the PFK1-encoded alpha-subunit) or 868 (for the PFK2-encoded beta-subunit) is crucial to ac...

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Detalhes bibliográficos
Main Authors: Kirchberger, J, Edelmann, A, Kopperschläger, G, Heinisch, J J
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220325/
https://ncbi.nlm.nih.gov/pubmed/10377240
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