Kinetic basis for selective inhibition of cyclo-oxygenases.

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the formation of prostaglandins by cyclo-oxygenases (COX). The discovery of a second COX isoform (COX-2) associated with inflammation led to agents that selectively inhibit COX-2, e.g. celecoxib. We evaluated the kinetics of inhibition of celeco...

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Autori principali: Gierse, J K, Koboldt, C M, Walker, M C, Seibert, K, Isakson, P C
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1999
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220196/
https://ncbi.nlm.nih.gov/pubmed/10215599
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