Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications.

We have studied the effects of agonist and antagonist binding, agonist-induced activation and agonist-induced desensitization of the human tachykinin NK2 receptor mutated at polar residues Asn-51 [in transmembrane helix 1 (TM1)], Asp-79 (TM2) and Asn-303 (TM7), which are highly conserved in the tran...

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Detalhes bibliográficos
Main Authors: Donnelly, D, Maudsley, S, Gent, J P, Moser, R N, Hurrell, C R, Findlay, J B
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220127/
https://ncbi.nlm.nih.gov/pubmed/10085227
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