Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor.

We have shown previously that human apolipoprotein (apo)C1 transgenic mice exhibit hyperlipidaemia, due primarily to an impaired clearance of very-low-density lipoprotein (VLDL) particles from the circulation. In the absence of at least the low-density-lipoprotein receptor (LDLR), it was shown that...

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Detalhes bibliográficos
Main Authors: Jong, M C, van Dijk, K W, Dahlmans, V E, Van der Boom, H, Kobayashi, K, Oka, K, Siest, G, Chan, L, Hofker, M H, Havekes, L M
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220053/
https://ncbi.nlm.nih.gov/pubmed/10024503
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