Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIalpha.

Topoisomerase II (topo II), an essential enzyme for cell viability, is also the target for clinically important anti-neoplastic agents that stimulate topo II-mediated DNA scission. The role of alterations in topo IIalpha phosphorylation and its effect on drug-induced DNA damage and cytotoxicity were...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Aoyama, M, Grabowski, D R, Dubyak, G R, Constantinou, A I, Rybicki, L A, Bukowski, R M, Ganapathi, M K, Hickson, I D, Ganapathi, R
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219926/
https://ncbi.nlm.nih.gov/pubmed/9841887
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados