Comparative resistance of the 20S and 26S proteasome to oxidative stress.

Oxidatively modified ferritin is selectively recognized and degraded by the 20S proteasome. Concentrations of hydrogen peroxide (H2O2) higher than 10 micromol/mg of protein are able to prevent proteolytic degradation. Exposure of the protease to high amounts of oxidants (H2O2, peroxynitrite and hypo...

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Hauptverfasser: Reinheckel, T, Sitte, N, Ullrich, O, Kuckelkorn, U, Davies, K J, Grune, T
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1998
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219826/
https://ncbi.nlm.nih.gov/pubmed/9794805
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