Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf.

Treatment of cultured neonatal ventricular myocytes with oncogenic Ras increases their size and stimulates the re-expression of genes which are normally restricted to the fetal stage of ventricular development, including atrial natriuretic factor (ANF) and skeletal muscle (SkM)-alpha-actin. To deter...

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Bibliografski detalji
Glavni autori: Fuller, S J, Finn, S G, Downward, J, Sugden, P H
Format: Artigo
Jezik:Inglês
Izdano: 1998
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219775/
https://ncbi.nlm.nih.gov/pubmed/9761720
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