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RalGDS Couples Growth Factor Signaling to Akt Activation
The Akt kinase is a key regulator of cell proliferation and survival. It is activated in part by PDK1-induced phosphorylation. Here we show that RalGDS, a Ras effector protein that activates Ral GTPases, has a second function that promotes Akt phosphorylation by PDK1 by bringing these two kinases to...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology (ASM)
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2293091/ https://ncbi.nlm.nih.gov/pubmed/18285454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01917-07 |
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