Loop III region of platelet-derived growth factor (PDGF) B-chain mediates binding to PDGF receptors and heparin.

Site-directed mutagenesis of the platelet-derived growth factor (PDGF) B-chain was conducted to determine the importance of cationic amino acid residues (Arg160-Lys161-Lys162; RKK) located within the loop III region in mediating the biological and cell-association properties of the molecule. Binding...

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Autors principals: Schilling, D, Reid IV, J D, Hujer, A, Morgan, D, Demoll, E, Bummer, P, Fenstermaker, R A, Kaetzel, D M
Format: Artigo
Idioma:Inglês
Publicat: 1998
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219627/
https://ncbi.nlm.nih.gov/pubmed/9677323
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