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Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzyme.

The Met69-->Ile mutant of the OHIO-1 beta-lactamase, an SHV-family enzyme, is resistant to inactivation by beta-lactamase inhibitors. Analysis of purified Met69-->Ile enzyme reveals that its isoelectric point (pI 7.0) and CD spectrum are identical with those of the OHIO-1 enzyme. Levels of bet...

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Sonraí Bibleagrafaíochta
Main Authors: Lin, S, Thomas, M, Shlaes, D M, Rudin, S D, Knox, J R, Anderson, V, Bonomo, R A
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1998
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219605/
https://ncbi.nlm.nih.gov/pubmed/9735103
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