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Characterization of helical cleavages in type II collagen generated by matrixins.

Several vertebrate collagenases have been reported to cleave type II collagen, leading to irreversible tissue destruction in osteoarthritis. We have investigated the action of MMP-1 and MMP-13 on type II collagen by use of neoepitope antibodies and N-terminal sequencing. Previous studies have sugges...

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Autors principals: Vankemmelbeke, M, Dekeyser, P M, Hollander, A P, Buttle, D J, Demeester, J
Format: Artigo
Idioma:Inglês
Publicat: 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219184/
https://ncbi.nlm.nih.gov/pubmed/9480869
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