Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1).

Tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs) by forming a 1:1 stoichiometric complex, but the inhibition mechanism of these inhibitors is not known. Here we have investigated the reactive site of TIMP-1 by its proteinase susceptibility before and after for...

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Detalles Bibliográficos
Main Authors: Nagase, H, Suzuki, K, Cawston, T E, Brew, K
Formato: Artigo
Idioma:Inglês
Publicado: 1997
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1218541/
https://ncbi.nlm.nih.gov/pubmed/9224642
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