Identification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesis.

Human liver dihydrodiol dehydrogenase isoenzymes (DD1 and DD2), in which only seven amino acid residues are substituted, differ remarkably in specificity for steroidal substrates and inhibitor sensitivity: DD1 shows 20alpha-hydroxysteroid dehydrogenase activity and sensitivity to 1,10-phenanthroline...

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Hauptverfasser: Matsuura, K, Deyashiki, Y, Sato, K, Ishida, N, Miwa, G, Hara, A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1218315/
https://ncbi.nlm.nih.gov/pubmed/9173902
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