Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis.

The cytoskeletal protein non-erythroid alpha-spectrin is well documented as an endogenous calpain substrate, especially under pathophysiological conditions. In cell necrosis (e.g. maitotoxin-treated neuroblastoma SH-SY5Y cells), alpha-spectrin breakdown products (SBDPs) of 150 kDa and 145 kDa were p...

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Main Authors: Nath, R, Raser, K J, Stafford, D, Hajimohammadreza, I, Posner, A, Allen, H, Talanian, R V, Yuen, P, Gilbertsen, R B, Wang, K K
格式: Artigo
語言:Inglês
出版: 1996
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217843/
https://ncbi.nlm.nih.gov/pubmed/8920967
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