Isothiazolones interfere with normal matrix metalloproteinase activation and inhibit cartilage proteoglycan degradation.

A series of isothiazolones that inhibit pro-(matrix metallo-proteinase) (proMMP) activation but do not inhibit the active enzyme are effective as cartilage protectants in bovine nasal cartilage organ culture, preventing interleukin-1 (IL-1)-induced proteoglycan (aggrecan) degradation without affecti...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Arner, E C, Pratta, M A, Freimark, B, Lischwe, M, Trzaskos, J M, Magolda, R L, Wright, S W
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1996
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217638/
https://ncbi.nlm.nih.gov/pubmed/8809028
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