The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5).

The PDE4A (type IV) cAMP-specific, rolipram-inhibited phosphodiesterase RPDE-6 (RNPDE4A5), when transiently expressed in COS7 cells, could be complexed with the v-Src-SH3 domain expressed as a glutathione S-transferase (GST) fusion protein. RPDE-6 did not interact with GST itself. This complex was n...

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Bibliographic Details
Main Authors: O'Connell, J C, McCallum, J F, McPhee, I, Wakefield, J, Houslay, E S, Wishart, W, Bolger, G, Frame, M, Houslay, M D
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217616/
https://ncbi.nlm.nih.gov/pubmed/8761480
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