Human rhinovirus 2A proteinase mutant and its second-site revertants.

The 2A proteinases of human rhinoviruses are cysteine proteinases with marked similarities to serine proteinases. In the absence of a three-dimensional structure, we developed a genetical screening system for proteolytic activity and identified Phe-130 as a key residue. The mutation Phe-130-->Tyr...

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Bibliografiske detaljer
Main Authors: Luderer-Gmach, M, Liebig, H D, Sommergruber, W, Voss, T, Fessl, F, Skern, T, Kuechler, E
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217610/
https://ncbi.nlm.nih.gov/pubmed/8761474
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