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Prion diseases and the 'protein only' hypothesis: a theoretical dynamic study.

In the 'protein only' hypothesis, prion diseases are thought to result from the conformational change of a normal isoform of a prion protein (PrPC) to a protease-resistant, pathogenic form called PrPSc. This conversion rests on an autocatalytic process requiring the presence of pre-existin...

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Bibliografiske detaljer
Hovedforfatter: Laurent, M
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217585/
https://ncbi.nlm.nih.gov/pubmed/8761449
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