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Prion disease and the ‘protein-only hypothesis’

Prion disease is the only naturally occurring infectious protein misfolding disorder. The chemical nature of the infectious agent has been debated for more than half a century. Early studies on scrapie suggested that the unusual infectious agent might propagate in the absence of nucleic acid. The ‘p...

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Detalhes bibliográficos
Publicado no:Essays Biochem
Main Authors: Ma, Jiyan, Wang, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760854/
https://ncbi.nlm.nih.gov/pubmed/25131595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/bse0560181
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