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Evidence that residues exposed on the three-fold channels have active roles in the mechanism of ferritin iron incorporation.

Iron is thought to enter the ferritin cavity via the three-fold channel, which is lined in its narrowest part by the residues Asp-131 and Glu-134. We describe here variants of human ferritins with active and inactive ferroxidase centres having Asp-131 and Glu-134 substituted with Ala and Ala or with...

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Dettagli Bibliografici
Autori principali: Levi, S, Santambrogio, P, Corsi, B, Cozzi, A, Arosio, P
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217510/
https://ncbi.nlm.nih.gov/pubmed/8713073
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