Apoptosis induction resulting from proteasome inhibition.

Proteases are known to be involved in the apoptotic pathway. We report here that benzyloxycarbonyl (Z)-Leu-Leu-leucinal(ZLLLal), a leupeptin analogue, can induce apoptosis in MOLT-4 and L5178Y cells. ZLLLal is a cell-permeant inhibitor of proteasome. Among the protease inhibitors tested, only calpai...

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Autors principals: Shinohara, K, Tomioka, M, Nakano, H, Toné, S, Ito, H, Kawashima, S
Format: Artigo
Idioma:Inglês
Publicat: 1996
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217499/
https://ncbi.nlm.nih.gov/pubmed/8713062
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