Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT).

Stimulation of insulin release by glucose requires increased metabolism of glucose and a rise in cytosolic free Ca2+ in the pancreatic beta-cell. It is accompanied by increases in respiratory rate, pyridine and flavin nucleotide reduction state, intracellular pH and the ATP/ADP ratio. To test altern...

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Bibliographic Details
Main Authors: Civelek, V N, Deeney, J T, Kubik, K, Schultz, V, Tornheim, K, Corkey, B E
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217255/
https://ncbi.nlm.nih.gov/pubmed/8645138
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