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Phosphonamidate analogues of dipeptides with carboxypeptidase A and beta-lactamase-inhibitory activity: elucidation of the mechanism of beta-lactamase inhibition by electrospray mass spectrometry.

A series of phosphonamidate compounds with different P1' amino acid residues have been shown to be irreversible inactivators of the serine beta-lactamase from Enterobacter cloacae P99. The efficiency of inhibition (based on k2/K values) of P99 by these derivatives, ordered in decreasing potency...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Payne, D J, Bateson, J H, Tolson, D, Gasson, B, Khushi, T, Ledent, P, Frère, J M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1996
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217072/
https://ncbi.nlm.nih.gov/pubmed/8670057
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