Early proteolytic cleavage with loss of a C-terminal fragment underlies altered processing of the beta-galactosidase precursor in galactosialidosis.

Processing of human beta-galactosidase (beta-GAL) was studied in permanently transfected Chinese hamster ovary (CHO) cells and compared with that in normal cells and in cells from subjects with GM1-gangliosidosis, galactosialidosis and I-cell disease. Biosynthesis of beta-GAL in CHO cells results in...

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Main Authors: Okamura-Oho, Y, Zhang, S, Hilson, W, Hinek, A, Callahan, J W
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1216979/
https://ncbi.nlm.nih.gov/pubmed/8611156
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