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Ubiquinone Synthesis in Mitochondrial and Microsomal Subcellular Fractions of Pneumocystis spp.: Differential Sensitivities to Atovaquone

The lung pathogen Pneumocystis spp. is the causative agent of a type of pneumonia that can be fatal in people with defective immune systems, such as AIDS patients. Atovaquone, an analog of ubiquinone (coenzyme Q [CoQ]), inhibits mitochondrial electron transport and is effective in clearing mild to m...

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Detalhes bibliográficos
Main Authors: Basselin, Mireille, Hunt, Shannon M., Abdala-Valencia, Hiam, Kaneshiro, Edna S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1214522/
https://ncbi.nlm.nih.gov/pubmed/16087753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.4.8.1483-1492.2005
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