SHP-1 Binds and Negatively Modulates the c-Kit Receptor by Interaction with Tyrosine 569 in the c-Kit Juxtamembrane Domain

The SH2 domain-containing SHP-1 tyrosine phosphatase has been shown to negatively regulate a broad spectrum of growth factor- and cytokine-driven mitogenic signaling pathways. Included among these is the cascade of intracellular events evoked by stem cell factor binding to c-Kit, a tyrosine kinase r...

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Bibliographic Details

Published in:	Mol Cell Biol
Main Authors:	Kozlowski, Maya, Larose, Louise, Lee, Fai, Le, Duc Mingh, Rottapel, Robert, Siminovitch, Katherine A.
Format:	Artigo
Language:	Inglês
Published:	Taylor & Francis 1998
Subjects:	Cell Growth and Development
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC121439/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9528781/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.4.2089
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