Isolation of Mutants of Saccharomyces Cerevisiae Requiring DNA Topoisomerase I

Despite evidence that DNA topoisomerase I is required to relieve torsional stress during DNA replication and transcription, yeast strains with a top1 null mutation are viable and display no gross defects in DNA or RNA synthesis, possibly because other proteins provide overlapping functions. We isola...

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Bibliografiske detaljer
Main Authors: Sadoff, B. U., Heath-Pagliuso, S., Castano, I. B., Zhu, Y., Kieff, F. S., Christman, M. F.
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1206748/
https://ncbi.nlm.nih.gov/pubmed/8647385
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