Topoisomerase I-Dependent Viability Loss in Saccharomyces cerevisiae Mutants Defective in Both SUMO Conjugation and DNA Repair

Siz1 and Siz2/Nfi1 are the two Siz/PIAS SUMO E3 ligases in Saccharomyces cerevisiae. Here we show that siz1Δ siz2Δ mutants fail to grow in the absence of the homologous recombination pathway or the Fen1 ortholog RAD27. Remarkably, the growth defects of mutants such as siz1Δ siz2Δ rad52Δ are suppress...

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Detalhes bibliográficos
Main Authors: Chen, Xiaole L., Silver, Hannah R., Xiong, Ling, Belichenko, Irina, Adegite, Caroline, Johnson, Erica S.
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright © 2007 by the Genetics Society of America 2007
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013680/
https://ncbi.nlm.nih.gov/pubmed/17603101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.074708
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