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Estimating Effective Population Size and Mutation Rate from Sequence Data Using Metropolis-Hastings Sampling

We present a new way to make a maximum likelihood estimate of the parameter 4N(e)μ (effective population size times mutation rate per site, or θ) based on a population sample of molecular sequences. We use a Metropolis-Hastings Markov chain Monte Carlo method to sample genealogies in proportion to t...

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Bibliografiske detaljer
Main Authors: Kuhner, M. K., Yamato, J., Felsenstein, J.
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1206705/
https://ncbi.nlm.nih.gov/pubmed/7498781
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