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Inhibition by 6-mercaptopurine of purine phosphoribosyltransferases from Ehrlich ascites-tumour cells that are resistant to this drug

1. A strain of Ehrlich ascites-tumour cells that showed little inhibition of growth in the presence of 6-mercaptopurine accumulated less than 5% as much 6-thioinosine 5′-phosphate in vivo, in the presence of 6-mercaptopurine, as did the sensitive strain from which it was derived. 2. Specific activit...

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Bibliografiske detaljer
Main Authors: Atkinson, M. R., Murray, A. W.
Format: Artigo
Sprog:Inglês
Udgivet: 1965
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1206407/
https://ncbi.nlm.nih.gov/pubmed/14342251
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