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Mitochondrial DNA Complex I and III Mutations Associated with Leber's Hereditary Optic Neuropathy

Four new missense mutations have been identified through restriction analysis and sequencing of the mitochondrial DNAs (mtDNA) from Leber's hereditary optic neuropathy (LHON) patients who lacked the previously identified 11778 mutation. Each altered a conserved amino acid and correlated with th...

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Main Authors: Brown, M. D., Voljavec, A. S., Lott, M. T., Torroni, A., Yang, C. C., Wallace, D. C.
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1204789/
https://ncbi.nlm.nih.gov/pubmed/1732158
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