Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch

Specific recognition of phosphatidylinositol 3-phosphate [PtdIns(3)P] by the FYVE domain targets cytosolic proteins to endosomal membranes during key signaling and trafficking events within eukaryotic cells. Here, we show that this membrane targeting is regulated by the acidic cellular environment....

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Detalles Bibliográficos
Main Authors: Lee, Stephanie A., Eyeson, Rosemary, Cheever, Matthew L., Geng, Jinming, Verkhusha, Vladislav V., Burd, Christopher, Overduin, Michael, Kutateladze, Tatiana G.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201587/
https://ncbi.nlm.nih.gov/pubmed/16141328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503900102
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