Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch

Specific recognition of phosphatidylinositol 3-phosphate [PtdIns(3)P] by the FYVE domain targets cytosolic proteins to endosomal membranes during key signaling and trafficking events within eukaryotic cells. Here, we show that this membrane targeting is regulated by the acidic cellular environment....

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Lee, Stephanie A., Eyeson, Rosemary, Cheever, Matthew L., Geng, Jinming, Verkhusha, Vladislav V., Burd, Christopher, Overduin, Michael, Kutateladze, Tatiana G.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2005
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201587/
https://ncbi.nlm.nih.gov/pubmed/16141328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503900102
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