Preservation of Eumelanin Hair Pigmentation in Proopiomelanocortin-Deficient Mice on a Nonagouti (a/a) Genetic Background

The original strain of proopiomelanocortin (POMC)-deficient mice (Pomc(−/−) ) was generated by homologous recombination in 129X1/SvJ (A(w)/A(w))-derived embryonic stem cells using a targeting construct that deleted exon 3, encoding all the known functional POMC-derived peptides including αMSH, from...

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Главные авторы: Slominski, Andrzej, Plonka, Przemyslaw M., Pisarchik, Alexander, Smart, James L., Tolle, Virginie, Wortsman, Jacobo, Low, Malcolm J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2004
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201461/
https://ncbi.nlm.nih.gov/pubmed/15564334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2004-0733
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