The influence of locked nucleic acid residues on the thermodynamic properties of 2′-O-methyl RNA/RNA heteroduplexes

The influence of locked nucleic acid (LNA) residues on the thermodynamic properties of 2′-O-methyl RNA/RNA heteroduplexes is reported. Optical melting studies indicate that LNA incorporated into an otherwise 2′-O-methyl RNA oligonucleotide usually, but not always, enhances the stabilities of complem...

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Main Authors: Kierzek, Elzbieta, Ciesielska, Anna, Pasternak, Karol, Mathews, David H., Turner, Douglas H., Kierzek, Ryszard
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201327/
https://ncbi.nlm.nih.gov/pubmed/16155181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki789
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