Prolonged Survival of a Murine Model of Cerebral Malaria by Kynurenine Pathway Inhibition

C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hydroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until s...

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Bibliografiske detaljer
Main Authors: Clark, Catherine J., Mackay, Gillian M., Smythe, George A., Bustamante, Sonia, Stone, Trevor W., Phillips, R. Stephen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Fungal and Parasitic Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201246/
https://ncbi.nlm.nih.gov/pubmed/16041050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.8.5249-5251.2005
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