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Low-magnesium, trans-cleavage activity by type III, tertiary stabilized hammerhead ribozymes with stem 1 discontinuities

BACKGROUND: Low concentrations of free magnesium in the intracellular environment can present critical limitations for hammerhead ribozymes, especially for those that are designed for intermolecular (trans) cleavage of a host or pathogen RNA. Tertiary stabilizing motifs (TSM's) from natural and...

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Détails bibliographiques
Auteurs principaux: Burke, Donald H, Greathouse, S Travis
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2005
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1199579/
https://ncbi.nlm.nih.gov/pubmed/16095542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-6-14
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