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Biological Activity of a Mouse-Human Chimeric Immunoglobulin G2 Antibody to Cryptococcus neoformans Polysaccharide

The variable regions of the heavy and light chains of the protective murine monoclonal antibody (MAb) 2H1 (m2H1) were expressed with the human constant region genes for immunoglobulin G2 (IgG2) and kappa, respectively, to construct a chimeric antibody (ch2H1). ch2H1 retains the specificity of the pa...

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Udgivet i:Clin Diagn Lab Immunol
Principais autores: Westin Kwon, Katherine, Lendvai, Nikoletta, Morrison, Sherie, Trinh, K. Ryan, Casadevall, Arturo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Antibodies and Mediators of Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC119884/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11777857/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/CDLI.9.1.201-204.2002
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