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The effect of chemical modifications induced in insulin on the reactivity of the interchain disulphide bonds towards sodium sulphite

The reactivity of the three disulphide bridges of insulin towards sodium sulphite was studied by amperometric titration of the liberated thiol groups. In the native, acetylated or succinylated molecule two bridges react at pH7, but in the methylated or phenylcarbamoylated molecule only one bridge re...

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Detalhes bibliográficos
Main Authors: Massaglia, A., Pennisi, F., Rosa, U., Ronca-Testoni, S., Rossi, C. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 1968
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1198800/
https://ncbi.nlm.nih.gov/pubmed/5665887
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