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Association between Maternal Age and Meiotic Recombination for Trisomy 21

Altered genetic recombination has been identified as the first molecular correlate of chromosome nondisjunction in both humans and model organisms. Little evidence has emerged to link maternal age—long recognized as the primary risk factor for nondisjunction—with altered recombination, although some...

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Autors principals: Lamb, Neil E., Yu, Kai, Shaffer, John, Feingold, Eleanor, Sherman, Stephanie L.
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Human Genetics 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196437/
https://ncbi.nlm.nih.gov/pubmed/15551222
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