Neopeptide Antibiotics That Function as Opsonins and Membrane-Permeabilizing Agents for Gram-Negative Bacteria

We suggest a novel approach to enhancing antimicrobial drug action by utilizing engineered peptide conjugates. Our most potent conjugates, [fMLF]PMBN and [fMLF]PMEN, are nonapeptides derived from polymyxin B's (PMB's) cyclic moiety (Thr-Dab-cyclo[Dab-Dab-d-Phe-Leu-Dab-Dab-Thr], where Dab i...

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Detalhes bibliográficos
Main Authors: Tsubery, Haim, Yaakov, Hertzig, Cohen, Sofia, Giterman, Tal, Matityahou, Ariella, Fridkin, Mati, Ofek, Itzhak
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196242/
https://ncbi.nlm.nih.gov/pubmed/16048913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3122-3128.2005
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