Peptide Nucleic Acid Antisense Oligomer as a Therapeutic Strategy against Bacterial Infection: Proof of Principle Using Mouse Intraperitoneal Infection

Antisense oligodeoxynucleotides (ODNs) and their analogs have been successfully utilized to inhibit gene expression and bacterial growth in vitro or in cell culture. In this study, acpP-targeting antisense peptide nucleic acid (PNA) and its peptide conjugate were tested as potential antibacterial ag...

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Hlavní autoři: Tan, Xin-Xing, Actor, Jeffrey K., Chen, Yin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196239/
https://ncbi.nlm.nih.gov/pubmed/16048926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3203-3207.2005
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