Emergence of Fluoroquinolone Resistance in Mycobacterium tuberculosis during Continuously Dosed Moxifloxacin Monotherapy in a Mouse Model

Fluoroquinolone resistance in tuberculosis may rapidly emerge. Mice infected with high titers of aerosolized Mycobacterium tuberculosis and treated for 8 weeks with four concentrations of moxifloxacin (0.125, 0.25, 0.50, and 1.0%) mixed into the diet had drug concentrations of 2.4, 4.1, 5.3, and 17....

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Detalhes bibliográficos
Main Authors: Ginsburg, Amy Sarah, Sun, Ronggai, Calamita, Heather, Scott, Cherise P., Bishai, William R., Grosset, Jacques H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195434/
https://ncbi.nlm.nih.gov/pubmed/16127087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3977-3979.2005
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