Mutations Associated with Sulfadoxine-Pyrimethamine and Chlorproguanil Resistance in Plasmodium falciparum Isolates from Blantyre, Malawi

We conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unre...

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Main Authors: Alker, Alisa P., Mwapasa, Victor, Purfield, Anne, Rogerson, Stephen J., Molyneux, Malcolm E., Kamwendo, Deborah D., Tadesse, Eyob, Chaluluka, Ebbie, Meshnick, Steven R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195417/
https://ncbi.nlm.nih.gov/pubmed/16127071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3919-3921.2005
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