In Vitro Selection and Analysis of Human Immunodeficiency Virus Type 1 Resistant to Derivatives of β-2′,3′-Didehydro-2′,3′-Dideoxy-5-Fluorocytidine

Serial passage of human immunodeficiency virus type 1 in MT-2 cells in increasing concentrations of the d- and l-enantiomers of β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine (d4FC) resulted in the selection of viral variants with reverse transcriptase substitutions M184I or M184V for l-d4FC and I...

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Main Authors: Hammond, Jennifer L., Parikh, Urvi M., Koontz, Dianna L., Schlueter-Wirtz, Susan, Chu, Chung K., Bazmi, Hengameh Z., Schinazi, Raymond F., Mellors, John W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195387/
https://ncbi.nlm.nih.gov/pubmed/16127074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3930-3932.2005
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