INTERFERON α ACTIVATES NF-κ B IN JAK1-DEFICIENT CELLS THROUGH A TYK2-DEPENDENT PATHWAY

In addition to activating members of the STAT transcription factor family, IFN α/β activates the NF-κ B transcription factor. To determine the role of the JAK-STAT pathway in NF-κ B activation by IFN, we examined NF-κ B activation in JAK1-deficient mutant human fibrosarcoma cells. In wild-type fibro...

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Bibliographic Details
Main Authors: Yang, Chuan He, Murti, Aruna, Valentine, William J., Du, Ziyun, Pfeffer, Lawrence M.
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1193649/
https://ncbi.nlm.nih.gov/pubmed/15883164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M413721200
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