Ubiquitylation of Cdk9 by Skp2 Facilitates Optimal Tat Transactivation

By recruiting the positive transcriptional elongation factor b (P-TEFb) to paused RNA polymerase II, the transactivator Tat stimulates transcriptional elongation of the human immunodeficiency virus type 1 (HIV-1) genome. We found that cyclin-dependent kinase 9 (Cdk9), the catalytic subunit of P-TEFb...

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Detalhes bibliográficos
Main Authors: Barboric, Matjaz, Zhang, Fan, Besenicar, Mojca, Plemenitas, Ana, Peterlin, B. Matija
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1193628/
https://ncbi.nlm.nih.gov/pubmed/16103164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.17.11135-11141.2005
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