Endothelial Cells Promote Human Immunodeficiency Virus Replication in Nondividing Memory T Cells via Nef-, Vpr-, and T-Cell Receptor-Dependent Activation of NFAT

Human endothelial cells (ECs) enhance human immunodeficiency virus (HIV) replication within CD4(+) memory T cells by 50,000-fold in a Nef-dependent manner. Here, we report that EC-mediated HIV type 1 replication is also dependent on an intact vpr gene. Moreover, we demonstrate that despite a require...

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Detalhes bibliográficos
Main Authors: Choi, Jaehyuk, Walker, Jason, Talbert-Slagle, Kristina, Wright, Paulette, Pober, Jordan S., Alexander, Louis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1193601/
https://ncbi.nlm.nih.gov/pubmed/16103171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.17.11194-11204.2005
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