Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection

Previous studies indicate a pivotal role for complement in mediating both local and remote injury following ischemia and reperfusion of the intestine. Here, we report on the use of a mouse model of intestinal ischemia/reperfusion injury to investigate the strategy of targeting complement inhibition...

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Bibliographische Detailangaben
Hauptverfasser: Atkinson, Carl, Song, Hongbin, Lu, Bo, Qiao, Fei, Burns, Tara A., Holers, V. Michael, Tsokos, George C., Tomlinson, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2005
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190375/
https://ncbi.nlm.nih.gov/pubmed/16127466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25208
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