hnRNP K Binds a Core Polypyrimidine Element in the Eukaryotic Translation Initiation Factor 4E (eIF4E) Promoter, and Its Regulation of eIF4E Contributes to Neoplastic Transformation

Translation initiation factor eukaryotic translation initiation factor 4E (eIF4E) plays a key role in regulation of cellular proliferation. Its effects on the m(7)GpppN mRNA cap are critical because overexpression of eIF4E transforms cells, and eIF4E function is rate-limiting for G(1) passage. Altho...

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Detalhes bibliográficos
Main Authors: Lynch, Mary, Chen, Li, Ravitz, Michael J., Mehtani, Sapna, Korenblat, Kevin, Pazin, Michael J., Schmidt, Emmett V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190351/
https://ncbi.nlm.nih.gov/pubmed/16024782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6436-6453.2005
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